Can changes in cholesterol levels affect memory? Study says Yes

High cholesterol level is in itself a huge risk to the health. It can affect all internal organs and their functioning. Additionally, new research says that changes in cholesterol levels may affect your memory. American Heart Association Scientists identified Apolipoprotein E (ApoE) as the fundamental genetic cause of sporadic AD when the discovery was made. The metabolism of lipids depends on ApoE since this protein maintains lipid pathways in both brain tissue and the peripheral system.

According to Dr. Sakshe Jain, consultant psychiatrist, Ruby hall clinic, Pune, “The brain depends on cholesterol for proper functionality because this lipid forms essential parts of neuronal membranes and facilitates synaptic plasticity processes. Inside the brain ApoE functions as the primary lipid transporter because it delivers adequate lipids to neurons for their operational needs. Medical researchers have identified ApoE4 as a main susceptibility factor among all ApoE variants to develop AD. Research has identified ApoE4 as a risk factor for AD progression because it creates excessive brain cholesterol buildup.”
Scientists now confirm that impaired cholesterol management systems in the body increase the pace at which dementia progresses toward its end stages. Higher cholesterol levels will start an inflammatory response and generate amyloid plaques together with oxidative stress that identify as the main indicators of Alzheimer's disease brain pathology. Extremely low amounts of cholesterol create difficulties in brain health because cholesterol functions as a vital component for proper brain operations.

Researching dementia requires careful study of how cholesterol affects its development, even though its precise involvement remains disputed. All evidence points to managing proper cholesterol levels. People can lower their risk for cognitive decline through necessary medications combined with lifestyle changes, which include dietary and exercise modifications.
The health of our brain depends heavily on cholesterol just as much as cardiovascular wellness does. Added scientific evidence is required to validate cholesterol modulation as a future therapeutic approach for dementia prevention or delay.