James Madison vs Louisville Prediction, Picks & Odds | 05 Sep 2025
College Football Betting Preview: James Madison vs Louisville
James Madison meet Louisville in this NCAAF Week 2 matchup at L&N Federal Credit Union Stadium, with kickoff scheduled for 07:00 on Saturday 6 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.
Side With Louisville to Win Big
Louisville can finish well clear of James Madison and that means we’re going for them against the spread. There is 1.95 on offer that the favorites are able to cover a -13.5 line.
Riding with our spread recommendation? Grab the latest Stake promo code and read our full review of the platform before locking in your pick.
Teams’ Last Clash Saw 34-10 Louisville Win
James Madison Dukes previous game saw them claim a 45-10 home win over Weber State Wildcats at Bridgeforth Stadium.
Louisville Cardinals won their last game, beating Eastern Kentucky Colonels at home. It was a 51-17 win at L&N Federal Credit Union Stadium.
Head-to-Head Statistics
The scoreline was 34-10 in favor of Louisville when they last played James Madison, with the matchup taking place at L&N Federal Credit Union Stadium.
Quarterbacks
Alonza Barnett III
Miller Moss
James Madison vs Louisville Prediction & Picks
Tackle James Madison vs Louisville with all the betting insight you need, including our match prediction, scoreline forecast, key player prop selections and a hand-picked bet builder.
Game Prediction
There’s a case for taking the 1.95 that Louisville can overcome the -13.5 in this college football battle. They should be capable of a sizeable win and that means we’re backing the favorites against the spread.
Team news plays a key role in our college football forecasts and we’re always tracking players with injury concerns. We also stay on top of the form guide, supported by detailed stats that help paint a clearer picture of what to expect
Key James Madison vs Louisville stats:
Louisville -13.5 Probability
The best betting apps imply that our pick has a 51.3% chance of winning. After careful examination, our analysts have this probability close to 60%. This college wager can therefore be backed with confidence.
If the initial odds don’t grab your fancy, there’s the option to shoot for more juice by moving the line when it comes to your spread pick. It all comes down to how confident you feel.
Don’t place your bets without seeing the latest offers. Our in-depth guide helps you find the best welcome bonuses available today.
Best Bet
Player Prop Picks
Miller Moss (Louisville) is available at 1.88 to go beyond over 250.5 passing yards. The line for QB Passing Yards looks attractive and we’re confident of securing a return.
The odds for Isaac Brown (Louisville) to go over 99.5 rushing yards are 1.88. We believe it makes sense to stick with him on the Over and bettors can be confident in this Player Rushing Yards pick.
Same Game Parlay Picks
Get in the game with a same game parlay. Our picks are Louisville to cover the -13.5 spread, Over 55.5 on the total and Miller Moss (Louisville) to have Over 250.5 passing yards.
Many betting sites now allow you to place a same game parlay on each individual football game. It means that you can create a personalised wager at bigger odds, with there generally being no limit as to the number of picks.
Correct Score Prediction
20
-
42
Louisville
There are lots of different ways to back Louisville on the correct score betting and something like 42-20 in their favor might be along the right lines at massive odds.
James Madison vs Louisville Odds
The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.
Louisville Win on the Cards According to the Books
The latest Moneyline betting odds give Louisville a 88% chance of winning this college game which means they’re overwhelming 1.14 favorites with the sportsbooks. For those wanting to back James Madison, you will find 5.80 about the underdogs.
The spread is calculated to be 14.5, while total points comes in at 54.5. A wager on the Totals allows football bettors to use the latest data to good effect. Those that want to back Under 54.5 can find odds of 1.95 available.
Consider every angle when placing your college football wagers. The best betting sites have a huge selection of team props and game lines and it’s all about finding a bet which matches your prediction of the game.
Isaac Brown Favorite to Be First TD Scorer
The First Touchdown Scorer favorite is Isaac Brown at 4.20. Similar odds can be found if you’re interested in this player to register the final TD.
Touchdown
Receiving Yards
Rushing Yards
Passing Yards
Micro Betting
It’s possible to use stats to your advantage when it comes to college football micro betting, especially if you’re predicting outcomes such as the Next Drive Result. Check out the live player, score and team props and see if you can find an angle.
Louisville Sitting on Seven Wins in Previous Ten at Home
Louisville are 7-3 in their last 10 home games, scoring 39.80 points per contest and conceding 21.00.
James Madison have gone 6-4 across their last 10 games games on the road, scoring 32.70 points per contest and conceding 24.00.
The last time Louisville faced James Madison at L&N Federal Credit Union Stadium, they won 34-10.
| Last 10 Games | W-L | P | PF | PA | O55.5 | U55.5 | |
|---|---|---|---|---|---|---|---|
 Louisville Home Stats |
7-3 | 60.80 | 39.80 | 21.00 | 6 | 4 | |
 James Madison Away Stats |
6-4 | 56.70 | 32.70 | 24.00 | 4 | 6 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O55.5 = Games Over 55.5 Points
- U55.5 = Games Under 55.5 Points
Last 5 & H2H
Latest regular season and playoff games stats.
James Madison Dukes Stats
Louisville Cardinals Stats
- 6 wins and 4 defeats in the last 10 games
- 6 wins and 4 defeats in the last 10 games on the road
- +13.5 Betting Line: Have covered the spread in 8 of the last 10 games
- +13.5 Betting Line on the Road: Have covered the spread in 8 of the last 10 games on the road
- -13.5 Betting Line: Have covered the spread in 3 of the last 10 games
- -13.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games
- Game Totals: An average of 50.80 pts in the previous 10 games
- Game Totals on the Road: An average of 56.70 pts in the previous 10 games on the road
- Over 55.5: Covered in 2 of the previous 10 games
- Over 55.5 on the Road: Covered in 4 of the previous 10 games on the road
- Team Totals: Have scored an average of 30.20 pts and allowed 20.60 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 32.70 pts and allowed 24.00 pts in the last 10 games on the road
- Game Totals: An average of 62.50 pts in the previous 10 games
- Game Totals at Home: An average of 60.80 pts in the previous 10 home games
- Over 55.5: Covered in 6 of the previous 10 games
- Over 55.5 at Home: Covered in 6 of the previous 10 home games
- Team Totals: Have scored an average of 35.90 pts and allowed 26.60 pts in the last 10 games
- Team Totals at Home: Have scored an average of 39.80 pts and allowed 21.00 pts in the last 10 home games
NCAAF Standings Select Season
| Atlantic Coast | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Boston College
|
1 | 0 | 66 | 10 | 56 | 1-0 | 0-0 | 1W |
NC State
|
2 | 0 | 59 | 48 | 11 | 2-0 | 0-0 | 2W |
California
|
1 | 0 | 34 | 15 | 19 | 0-0 | 1-0 | 1W |
Pittsburgh
|
2 | 0 | 106 | 26 | 80 | 2-0 | 0-0 | 2W |
Wake Forest
|
2 | 0 | 52 | 19 | 33 | 2-0 | 0-0 | 2W |
Miami
|
1 | 0 | 27 | 24 | 3 | 1-0 | 0-0 | 1W |
|
Louisville
|
2 | 0 | 79 | 31 | 48 | 2-0 | 0-0 | 2W |
Georgia Tech
|
2 | 0 | 86 | 32 | 54 | 1-0 | 1-0 | 2W |
Florida State
|
2 | 0 | 108 | 20 | 88 | 2-0 | 0-0 | 2W |
Clemson
|
1 | 1 | 37 | 33 | 4 | 1-1 | 0-0 | 1W |
Duke
|
1 | 1 | 64 | 62 | 2 | 1-1 | 0-0 | 1L |
SMU
|
1 | 1 | 87 | 61 | 26 | 1-1 | 0-0 | 1L |
Syracuse
|
1 | 1 | 53 | 65 | -12 | 1-0 | 0-1 | 1W |
Virginia
|
1 | 1 | 79 | 42 | 37 | 1-0 | 0-1 | 1L |
North Carolina
|
0 | 1 | 14 | 48 | -34 | 0-1 | 0-0 | 1L |
Stanford
|
0 | 1 | 20 | 23 | -3 | 0-0 | 0-1 | 1L |
Virginia Tech
|
0 | 1 | 11 | 24 | -13 | 0-0 | 0-1 | 1L |
| Sun Belt | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Appalachian State
|
2 | 0 | 54 | 24 | 30 | 1-0 | 1-0 | 2W |
Arkansas State
|
1 | 0 | 42 | 24 | 18 | 1-0 | 0-0 | 1W |
UL Monroe
|
1 | 0 | 29 | 0 | 29 | 1-0 | 0-0 | 1W |
South Alabama
|
1 | 0 | 38 | 21 | 17 | 1-0 | 0-0 | 1W |
Texas State
|
2 | 0 | 95 | 63 | 32 | 1-0 | 1-0 | 2W |
|
James Madison
|
1 | 1 | 59 | 38 | 21 | 1-0 | 0-1 | 1L |
Troy State
|
1 | 1 | 54 | 47 | 7 | 1-0 | 0-1 | 1L |
Coastal Carolina
|
0 | 1 | 7 | 48 | -41 | 0-0 | 0-1 | 1L |
Georgia Southern
|
0 | 1 | 14 | 42 | -28 | 0-0 | 0-1 | 1L |
Georgia State
|
0 | 1 | 7 | 63 | -56 | 0-0 | 0-1 | 1L |
Marshall
|
0 | 1 | 7 | 45 | -38 | 0-0 | 0-1 | 1L |
Old Dominion
|
0 | 1 | 14 | 27 | -13 | 0-0 | 0-1 | 1L |
Louisiana
|
0 | 1 | 12 | 14 | -2 | 0-1 | 0-0 | 1L |
Southern Miss
|
0 | 1 | 17 | 34 | -17 | 0-1 | 0-0 | 1L |
Tulsa
New Mexico St
San Diego State
Washington State
Stanford
BYU
Sam Houston
Hawaii
Millonarios
Santa Fe
Betting Tips
21:00 - Sun 07 Sep
Europe World Cup Qualification
Georgia
Bulgaria
Betting Tips
22:15 - Sun 07 Sep
La Liga 2
Burgos
Las Palmas
Betting Tips
22:15 - Sun 07 Sep
La Liga 2
Real Sociedad B
Cádiz
Betting Tips
00:00 - Mon 08 Sep
League of Ireland
Shelbourne
Galway United
Betting Tips
00:00 - Mon 08 Sep
Europe World Cup Qualification
Lithuania
Netherlands
Betting Tips