Louisiana vs Eastern Michigan Prediction, Picks & Odds | 20 Sep 2025

College Football Betting Preview: Louisiana vs Eastern Michigan

Louisiana meet Eastern Michigan in this NCAAF Week 4 matchup at Rynearson Stadium, with kickoff scheduled for 03:30 on Sunday 21 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Back Eastern Michigan to Cause Louisiana Problems

Our prediction is that Eastern Michigan can outperform their odds against Louisiana. It leads us to a wager on the spread lines considering that an appealing +2.5 has been chalked up at 1.94.

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49-21 Louisiana Triumph in Previous H2H

Louisiana Ragin Cajuns were defeated in their previous game. On the road, they suffered a 52-10 reverse against Missouri Tigers at Faurot Field.

Eastern Michigan Eagles lost on the road in their last game, making it three straight defeats. Kentucky Wildcats won 48-23 at Kroger Field.

Head-to-Head Statistics

The last matchup between Louisiana and Eastern Michigan saw the former win. It was a 49-21 scoreline at Cajun Field.

Louisiana vs Eastern Michigan Prediction & Picks

Head into Louisiana vs Eastern Michigan with expert betting insights, including our main match prediction, best correct score pick and a value-driven bet builder. Dive into each section below for more.

Game Prediction

We’re very confident of Eastern Michigan staying close to the favorites in this college football battle, with our pick being that they’ll cover the spread. The +2.5 looks more than generous at 1.94.

Knowing which players are injured gives us a valuable edge when making college football predictions. After reviewing the form guide, we turn to the latest stats to shape our picks.

Key Louisiana vs Eastern Michigan stats:

• The +2.5 line has been covered by Eastern Michigan in 12 of their last 20 games at home.
• The -2.5 line hasn’t been covered by Louisiana in 4 of their last 5 games.
• The -2.5 line hasn’t been covered by Louisiana in 2 consecutive games on the road.

Eastern Michigan +2.5 Probability

If you go by the best sportsbooks, our pick has a 51.5% prospect of winning. After careful examination, our analysts calculate this probability to be closer to 60%. It’s the reason why we are recommending this college bet.

It’s good to explore all avenues and you might prefer bigger odds about the spread pick you want to make. Go ahead and move the line until you’re happy with the price.

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Best Bet

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Correct Score Prediction

Louisiana 27 - 30 Eastern Michigan

We’ll roll the dice and go for Eastern Michigan to register a 30-27 victory. We don’t think that there will be too much between the teams and we’re happy to take the huge odds.

Louisiana vs Eastern Michigan Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Latest Moneyline Odds Suggest a Tight Affair

You can choose Eastern Michigan at 2.12 or alternatively Louisiana who have betting odds of 1.75. The hosts have a 47% chance of victory in the eyes of the leading sportsbooks.

The spread is calculated to be 2.5, while total points comes in at 50.5. There are many ways to wager on football including the Totals. If you’re going for Under 50.5, this outcome can be backed at 1.91.

If you’re betting on college football, we recommend heading to the top betting apps and scanning through the many team props and game lines. There’s a chance to wager pre-game and in-game.

Player Props & Micro Betting

We’re fond of the quarterback and player props as an alternative to betting on the game lines. The gambling sites will have Player Kicking Points, Longest Rushing Attempt and Rushing Yards among the choices and you can take a view.

Micro betting provides a rollercoaster ride for college football bettors. It can be great to enjoy the live lines, with the opportunity to wager on the Next Scoring Play. Watch the live action before deciding which way to go.

Eastern Michigan Currently Sit on Three Straight Home Losses

Eastern Michigan have come up short in three consecutive outings at Rynearson Stadium. They are 4-6 in their last 10 home games, averaging 25.70 points on offense and surrendering 33.10 on defense.

Louisiana have six wins and four losses in the last 10 road games, averaging 24.60 points scored and 27.90 points allowed.

Last 10 Games		W-L	P	PF	PA	O50.5	U50.5
Eastern Michigan Home Stats		4-6	58.80	25.70	33.10	9	1
Louisiana Away Stats		6-4	52.50	24.60	27.90	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O50.5 = Games Over 50.5 Points
• U50.5 = Games Under 50.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Louisiana Ragin Cajuns Stats

Eastern Michigan Eagles Stats

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 games on the road

Moneyline

• 1 win and 9 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 home games

Point Spread

• -2.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -2.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• +2.5 Betting Line: Have covered the spread in 2 of the last 10 games
• +2.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 50.40 pts in the previous 10 games
• Game Totals on the Road: An average of 52.50 pts in the previous 10 games on the road
• Over 50.5: Covered in 4 of the previous 10 games
• Over 50.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 25.00 pts and allowed 25.40 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 24.60 pts and allowed 27.90 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 57.40 pts in the previous 10 games
• Game Totals at Home: An average of 58.80 pts in the previous 10 home games
• Over 50.5: Covered in 7 of the previous 10 games
• Over 50.5 at Home: Covered in 9 of the previous 10 home games
• Team Totals: Have scored an average of 22.20 pts and allowed 35.20 pts in the last 10 games
• Team Totals at Home: Have scored an average of 25.70 pts and allowed 33.10 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Mid-American	W	L	PF	PA	N. Pts	Home	Away	Strk
Bowling Green	2	1	69	54	15	2-0	0-1	1W
Buffalo	2	1	86	57	29	1-0	1-1	2W
Toledo	2	1	121	45	76	2-0	0-1	2W
Northern Illinois	1	1	28	37	-9	1-0	0-1	1L
Ball State	1	2	37	102	-65	1-0	0-2	1W
Central Michigan	1	2	36	122	-86	0-0	1-2	2L
Kent State	1	2	63	110	-47	1-1	0-1	2L
Ohio	1	2	57	81	-24	1-0	0-2	1L
Akron	0	3	28	109	-81	0-1	0-2	3L
Eastern Michigan	0	3	73	128	-55	0-1	0-2	3L
Massachusetts	0	3	43	116	-73	0-2	0-1	3L
Miami (OH)	0	2	17	62	-45	0-0	0-2	2L
Western Michigan	0	3	36	94	-58	0-1	0-2	3L

Sun Belt	W	L	PF	PA	N. Pts	Home	Away	Strk
Appalachian State	2	1	76	62	14	1-0	1-1	1L
Old Dominion	2	1	113	59	54	1-0	1-1	2W
Southern Miss	2	1	93	76	17	2-1	0-0	2W
Texas State	2	1	110	97	13	1-0	1-1	1L
James Madison	1	1	59	38	21	1-0	0-1	1L
UL Monroe	1	1	29	73	-44	1-0	0-1	1L
Coastal Carolina	1	2	20	86	-66	1-1	0-1	1L
Georgia Southern	1	2	75	135	-60	1-0	0-2	1W
Georgia State	1	2	60	122	-62	1-1	0-1	1W
Marshall	1	2	65	73	-8	1-1	0-1	1W
Arkansas State	1	2	72	104	-32	1-1	0-1	2L
Louisiana	1	2	56	76	-20	1-1	0-1	1L
South Alabama	1	2	84	85	-1	1-1	0-1	2L
Troy State	1	2	61	75	-14	1-1	0-1	2L