Syracuse vs Clemson Prediction, Picks & Odds | 20 Sep 2025

College Football Betting Preview: Syracuse vs Clemson

Syracuse square off against Clemson in this NCAAF Week 4 matchup at Memorial Stadium, with kickoff scheduled for 00:00 on Sunday 21 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Syracuse Look Value for This Matchup

Our prediction is that Syracuse might not be beaten heavily by Clemson. The underdogs have been afforded a generous +16.5 and we recommend backing them at odds of 1.98.

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Clemson Have Enjoyed Upper Hand Over Syracuse

Syracuse Orange claimed a home victory in their previous game. A 66-24 triumph against Colgate Raiders at JMA Wireless Dome made it back-to-back wins.

Clemson Tigers suffered a defeat in their last game. A 24-21 scoreline occurred on the road at Bobby Dodd Stadium against Georgia Tech Yellow Jackets.

Head-to-Head Statistics

Clemson beat Syracuse when the teams last met. It was a 31-14 scoreline at JMA Wireless Dome. In the past 5 meetings between these teams, Clemson have won all of them.

Quarterbacks

Steve Angeli

Cade Klubnik

Syracuse vs Clemson Prediction & Picks

From our key match prediction to correct score pick, top player prop insights and a builder tailored for value — our Syracuse vs Clemson betting tips covers it all.

Game Prediction

It’s all about Syracuse to stay ahead of the curve against the favorites. We really like this wager and the +16.5 spread looks generous at odds of 1.98 for this college football battle.

jeetwin-gaming.com brings strong college football expertise, built on knowing the team news as soon as it’s confirmed. Recent form plays a big part in our CFB picks and we always back it up with the most relevant stats.

Key Syracuse vs Clemson stats:

• The +16.5 line has been covered by Syracuse in 17 of their last 20 games.
• The +16.5 line has been covered by Syracuse in 8 of their last 10 games.
• The +16.5 line has been covered by Syracuse in 2 consecutive games.
• The -16.5 line hasn’t been covered by Clemson in 6 consecutive games.
• The -16.5 line hasn’t been covered by Clemson in 9 of their last 10 games.
• The -16.5 line hasn’t been covered by Clemson in 14 of their last 20 games.

Syracuse +16.5 Probability

According to the top sportsbooks, our pick has a 50.5% chance of delivering a return. Our experts think there’s a stronger chance of success and calculate the probability to be 55-60%. This is why we regard this as a value wager.

There’s the option to move the line for your point spread pick and this enables bettors to get bigger odds. If you’re prepared for additional risk, you can get more bang for your buck.

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Best Bet

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Player Prop Picks

Correct Score Prediction

Syracuse 27 - 34 Clemson

There are lots of different betting angles including the chance to bet on Clemson on the correct score lines. For example, a 34-27 win in their favor is available at huge odds.

Syracuse vs Clemson Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Taking No Chances With Clemson

The favorites are 89% likely to win according to the sportsbooks’ latest Money Line odds, with Clemson priced at 1.12 to triumph in this college game. For those wanting to oppose the market leader, you can get 6.70 about Syracuse.

The current spread is 16.5 and total points is 54.5. Having a bet on the Totals is one of the most popular football wagers. There’s the chance to back Under 54.5 at 1.87.

You’ll find a great variety of team props and game lines for most college football showdowns. The best betting apps provide a strong mix of pre-game and in-game options to suit your betting style.

Player Odds

Receiving Yards

Rushing Yards

Passing Yards

Last Ten Home Games Have Produced Seven Wins for Clemson

Clemson are 7-3 in their last 10 home games, averaging 36.70 points scored and 21.70 points allowed.

Syracuse have a 4-6 record in their last 10 road games, scoring 25.80 points per contest and conceding 35.10.

Clemson beat Syracuse 27-21 when they last met at Memorial Stadium.

Last 10 Games		W-L	P	PF	PA	O55.5	U55.5
Clemson Home Stats		7-3	58.40	36.70	21.70	4	6
Syracuse Away Stats		4-6	60.90	25.80	35.10	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O55.5 = Games Over 55.5 Points
• U55.5 = Games Under 55.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Syracuse Orange Stats

Clemson Tigers Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +16.5 Betting Line: Have covered the spread in 8 of the last 10 games
• +16.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• -16.5 Betting Line: Have covered the spread in 1 of the last 10 games
• -16.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 67.90 pts in the previous 10 games
• Game Totals on the Road: An average of 60.90 pts in the previous 10 games on the road
• Over 55.5: Covered in 7 of the previous 10 games
• Over 55.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 35.90 pts and allowed 32.00 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 25.80 pts and allowed 35.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 47.40 pts in the previous 10 games
• Game Totals at Home: An average of 58.40 pts in the previous 10 home games
• Over 55.5: Covered in 3 of the previous 10 games
• Over 55.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 25.00 pts and allowed 22.40 pts in the last 10 games
• Team Totals at Home: Have scored an average of 36.70 pts and allowed 21.70 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	W	L	PF	PA	N. Pts	Home	Away	Strk
California	3	0	96	32	64	2-0	1-0	3W
Florida State	2	0	108	20	88	2-0	0-0	2W
Georgia Tech	3	0	110	53	57	2-0	1-0	3W
Louisville	2	0	79	31	48	2-0	0-0	2W
Miami	3	0	121	39	82	3-0	0-0	3W
NC State	3	0	93	72	21	2-0	1-0	3W
Wake Forest	2	1	76	53	23	2-1	0-0	1L
Virginia	2	1	134	58	76	2-0	0-1	1W
SMU	2	1	115	71	44	1-1	1-0	1W
Syracuse	2	1	119	89	30	2-0	0-1	2W
Pittsburgh	2	1	130	57	73	2-0	0-1	1L
North Carolina	2	1	75	57	18	1-1	1-0	2W
Boston College	1	2	126	82	44	1-0	0-2	2L
Clemson	1	2	58	57	1	1-1	0-1	1L
Duke	1	2	91	96	-5	1-1	0-1	2L
Stanford	1	2	53	70	-17	1-0	0-2	1W
Virginia Tech	0	3	57	113	-56	0-2	0-1	3L