NFL Betting Preview: Chiefs vs Chargers

The AFC champions and Super Bowl runners-up Kansas City Chiefs lock horns with the Los Angeles Chargers in this NFL Week 1 matchup at SoFi Stadium, with kickoff scheduled for 08:00 on Saturday 6 September. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Don’t Write Off Chargers

The market might have underrated the Chargers and 1.95 makes lots of appeal considering the underdogs are +3 on the spread. Back them to cover the line against the Chiefs.

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Chiefs Are 8 From 10 on the H2H

Kansas City Chiefs lost their last game, a 40–22 defeat to the Philadelphia Eagles in Super Bowl LIX at Caesars Superdome. It marked the franchise’s third consecutive Super Bowl appearance.

The Chiefs generated 275 total yards of offense, with 226 coming through the air and 49 on the ground. They picked up 12 first downs and scored three touchdowns, all via the passing game.

Los Angeles Chargers suffered a defeat in their last game. A 32-12 scoreline occurred on the road at NRG Stadium against Houston Texans. The Chargers recorded 261 yards, split between 211 passing and 50 rushing yards. The offense produced 15 first downs and scored one touchdown.

Head-to-Head Statistics

The Chiefs won the most recent matchup between these teams. A 19-17 victory was registered against the Chargers at GEHA Field at Arrowhead Stadium. In the past 10 H2H meetings, the Chiefs have won eight.

Quarterbacks

Patrick Mahomes

Justin Herbert

Chiefs vs Chargers Prediction & Picks

Get the edge with our best Chiefs vs Chargers tips: a key match prediction, correct score recommendation, top player prop bets and a ready-made bet builder.

Game Prediction

We’re confident that the Chargers can push for a victory in this NFL matchup and the +3 about the underdogs on the spread makes appeal. Take 1.95 that they cover the line.

The NFL handicappers at jeetwin-gaming.com stay on top of injuries and team form that could impact the outcome. We also leave no stone unturned when analyzing the latest stats to support every prediction.

Key Chiefs vs Chargers stats:

The +3 line has been covered by Chargers in 15 of their last 20 games at home.
The +3 line has been covered by Chargers in 7 of their last 10 games.
The -3 line hasn’t been covered by Chiefs in 2 consecutive games on the road.
The +3 line has been covered by Chargers in 7 of their last 10 games against Chiefs.

Chargers +3 Probability

The top NFL sportsbooks make it a 51.3% chance that our pick is settled as a winner. However, our research has found that the actual probability is closer to 60%. This is why we regard this as a value bet.

Looking for Bigger Odds?

If the initial odds don’t grab your fancy, there’s the option to shoot for more juice by moving the line when it comes to your point spread pick. It all comes down to how confident you feel.

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Best Bet

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Published 14:26, 04 September 2025

Player Prop Picks

Top Pick: Justin Herbert Over 231.5 Passing Yards

Justin Herbert (Chargers) can be backed at 1.88 to go beyond 231.5 passing yards. We’re confident in taking him to cover the QB Passing Yards line and bettors can place this bet with confidence.

Latest Justin Herbert Player Prop Odds

Touchdown

Passing Yards

Rushing Yards

Travis Kelce Anytime TD

You can back Travis Kelce (Chiefs) at odds of 2.55 to score a TD. Based on all the evidence, we're happy to back him to punch it in on the Anytime Touchdown Scorer market.

Latest Travis Kelce Player Prop Odds

Touchdown

Receiving Yards

Same Game Parlay Picks

Spread Chargers +3

Totals Over 46.5

Passing Yards Justin Herbert Over 231.5

We’ve got a same game parlay with three options: Chargers +3, Over 46.5 points and Justin Herbert (Chargers) to have Over 231.5 passing yards.

A same game parlay allows football bettors to place a multiple wager on the same game. You can go through the available betting lines and select the outcomes that you think will happen. The odds for each pick are then combined together.

T&C apply. Gamble responsibly 18+

Correct Score Prediction

Chiefs

23 - 27 Chargers logo

Chargers

We’ll throw a dart when it comes to the Chargers claiming a 27-23 victory. This correct score prediction is available at monster odds and could be an entertaining wager to place.

Chiefs vs Chargers Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Latest Odds Suggest Chiefs Win

With a 63% chance of securing victory, Kansas City Chiefs are favorites for this game and the sportsbooks have them at betting odds of 1.58. For those wanting to oppose the market leader, you can get 2.44 about Los Angeles Chargers.

The spread currently stands at 3 and the total points line is 47.5. NFL fans regularly enjoy the opportunity to bet on the Totals. There’s the chance to back Under 47.5 at 1.87.

National Football League fans are spoilt for choice thanks to the wide range of game lines and team props which are available for every game on the coupon. Visit the top betting apps and find the best value wagers.

Moneyline

Point Spread

Total Points

Xavier Worthy Favorite to Be First TD Scorer

There is 2.10 available that Xavier Worthy scores a TD at any stage. He is available at 7.50 to record the first touchdown which makes him favorite.

Touchdown

Xavier Worthy (Chiefs)

Omarion Hampton (Chargers)

Isiah Pacheco (Chiefs)

Rashee Rice (Chiefs)

View More View Less

Receiving Yards

Ladd McConkey (Chargers)

Rashee Rice (Chiefs)

Xavier Worthy (Chiefs)

Travis Kelce (Chiefs)

View More View Less

Rushing Yards

Omarion Hampton (Chargers)

Isiah Pacheco (Chiefs)

Najee Harris (Chargers)

Kareem Hunt (Chiefs)

View More View Less

Passing Yards

Patrick Mahomes (Chiefs)

Justin Herbert (Chargers)

Micro Betting

An increasing number of bettors are now enjoying micro betting on the NFL and it’s something which is available on an in-game basis. Wait for the action to start and then wager on something specific to happen.

Best Betting Offers

SoFi Stadium

Chiefs Have Won Last Five Head-to-Head Meetings at SoFi Stadium

The Chargers have a 5-5 record in their last 10 home games, averaging 22.70 points on offense and surrendering 21.30 on defense.

The Chiefs have a 7-3 record in their last 10 games on the road, averaging 21.70 points scored and 21.70 points allowed.

The Chiefs earned a 17-10 win over the Chargers the last time they played at SoFi Stadium. From 5 head-to-head games at SoFi Stadium, the Chiefs have been victorious in all.

Last 10 Games		W-L	P	PF	PA	O46.5	U46.5
Chargers Home Stats		5-5	44.00	22.70	21.30	4	6
Chiefs Away Stats		7-3	43.40	21.70	21.70	4	6

W-L = Wins-Losses
P = Avg. Points
PF = Avg. Points For
PA = Avg. Points Against
O46.5 = Games Over 46.5 Points
U46.5 = Games Under 46.5 Points

Last 5 & H2H

All
Home
Away

Last 5 Games

Chiefs

NFL Playoffs: 10/02 Chiefs22 Eagles 40
NFL Playoffs: 27/01 Bills29 Chiefs 32
NFL Playoffs: 18/01 Texans14 Chiefs 23
NFL: 05/01 Chiefs0 Broncos 38
NFL: 25/12 Chiefs29 Steelers 10

Chargers

NFL Playoffs: 11/01 Chargers12 Texans 32
NFL: 05/01 Chargers34 Raiders 20
NFL: 28/12 Chargers40 Patriots 7
NFL: 20/12 Broncos27 Chargers 34
NFL: 15/12 Buccaneers40 Chargers 17

Head to Head

Chiefs vs Chargers

NFL: 09/12 2024 Chargers 17 Chiefs 19
NFL: 29/09 2024 Chiefs 17 Chargers 10
NFL: 07/01 2024 Chiefs 13 Chargers 12
NFL: 22/10 2023 Chargers 17 Chiefs 31
NFL: 21/11 2022 Chiefs 30 Chargers 27
NFL: 16/09 2022 Chargers 24 Chiefs 27
NFL: 17/12 2021 Chiefs 34 Chargers 28
NFL: 26/09 2021 Chargers 30 Chiefs 24
NFL: 03/01 2021 Chargers 38 Chiefs 21
NFL: 20/09 2020 Chiefs 23 Chargers 20

Team Stats

Latest regular season and playoff games stats.

Kansas City Chiefs Stats

Los Angeles Chargers Stats

Moneyline

8 wins and 2 defeats in the last 10 games
7 wins and 3 defeats in the last 10 games on the road

Moneyline

6 wins and 4 defeats in the last 10 games
5 wins and 5 defeats in the last 10 home games

Point Spread

-3 Betting Line: Have covered the spread in 6 of the last 10 games
-3 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

+3 Betting Line: Have covered the spread in 7 of the last 10 games
+3 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

Game Totals: An average of 44.00 pts in the previous 10 games
Game Totals on the Road: An average of 43.40 pts in the previous 10 games on the road
Over 46.5: Covered in 3 of the previous 10 games
Over 46.5 on the Road: Covered in 4 of the previous 10 games on the road
Team Totals: Have scored an average of 22.20 pts and allowed 21.80 pts in the last 10 games
Team Totals on the Road: Have scored an average of 21.70 pts and allowed 21.70 pts in the last 10 games on the road

Total Points

Game Totals: An average of 48.70 pts in the previous 10 games
Game Totals at Home: An average of 44.00 pts in the previous 10 home games
Over 46.5: Covered in 6 of the previous 10 games
Over 46.5 at Home: Covered in 4 of the previous 10 home games
Team Totals: Have scored an average of 25.50 pts and allowed 23.20 pts in the last 10 games
Team Totals at Home: Have scored an average of 22.70 pts and allowed 21.30 pts in the last 10 home games

Game Stats

Last 10 Games

Total Yards: Gained 304.60 Yds. Allowed 353.10 Yds
Rushing Yards: Gained 91.00 Yds. Allowed 130.90 Yds
Passing Yards: Gained 213.60 Yds. Allowed 222.20 Yds
Total Touchdowns: Scored 2.40 TD. Allowed 2.40 TD
Rushing Touchdowns: Scored 0.80 TD. Allowed 0.90 TD
Passing Touchdowns: Scored 1.60 TD. Allowed 1.40 TD
Total 1st Downs: Picked up 18.70. Allowed 21.00
Total Turnovers: Committed 0.40. Committed by opponents 1.20
Total Penalties: Committed 5.90. Committed by opponents 6.80
Penalty Yards: Lost 50.90 Yds. Gained 54.90 Yds

Game Stats

Last 10 Games

Total Yards: Gained 325.20 Yds. Allowed 351.30 Yds
Rushing Yards: Gained 101.60 Yds. Allowed 130.20 Yds
Passing Yards: Gained 223.60 Yds. Allowed 221.10 Yds
Total Touchdowns: Scored 2.60 TD. Allowed 2.40 TD
Rushing Touchdowns: Scored 1.00 TD. Allowed 0.50 TD
Passing Touchdowns: Scored 1.40 TD. Allowed 1.80 TD
Total 1st Downs: Picked up 20.30. Allowed 19.90
Total Turnovers: Committed 0.90. Committed by opponents 1.10
Total Penalties: Committed 5.50. Committed by opponents 6.90
Penalty Yards: Lost 39.70 Yds. Gained 65.20 Yds

Last 10 Games on the Road

Total Yards: Gained 306.00 Yds. Allowed 322.70 Yds
Rushing Yards: Gained 101.50 Yds. Allowed 109.40 Yds
Passing Yards: Gained 204.50 Yds. Allowed 213.30 Yds
Total Touchdowns: Scored 2.70 TD. Allowed 2.40 TD
Rushing Touchdowns: Scored 0.80 TD. Allowed 1.10 TD
Passing Touchdowns: Scored 1.90 TD. Allowed 1.20 TD
Total 1st Downs: Picked up 18.40. Allowed 19.90
Total Turnovers: Committed 1.10. Committed by opponents 1.50
Total Penalties: Committed 6.20. Committed by opponents 6.10
Penalty Yards: Lost 56.20 Yds. Gained 41.40 Yds

Last 10 Home Games

Total Yards: Gained 315.90 Yds. Allowed 358.50 Yds
Rushing Yards: Gained 110.10 Yds. Allowed 130.40 Yds
Passing Yards: Gained 205.80 Yds. Allowed 228.10 Yds
Total Touchdowns: Scored 2.20 TD. Allowed 2.30 TD
Rushing Touchdowns: Scored 1.00 TD. Allowed 0.60 TD
Passing Touchdowns: Scored 1.10 TD. Allowed 1.60 TD
Total 1st Downs: Picked up 18.50. Allowed 18.10
Total Turnovers: Committed 0.50. Committed by opponents 1.10
Total Penalties: Committed 5.30. Committed by opponents 6.50
Penalty Yards: Lost 37.90 Yds. Gained 61.20 Yds

Team News

Kansas City Chiefs @ Los Angeles Chargers Lineups

Los Angeles Chargers

Manager:

Jim Harbaugh

Kansas City Chiefs

Manager:

Andy Reid

Los Angeles Chargers Substitutes

0 Daiyan Henley
1 Quentin Johnston
3 Derwin James
6 Denzel Perryman
8 Omarion Hampton
9 Tre Harris
10 Justin Herbert
11 Cameron Dicker
12 Derius Davis
13 Keenan Allen
15 Ladd McConkey
16 J.K. Scott
20 Cam Hart
22 Najee Harris
22 Elijah Molden
24 Benjamin St-Juste
26 Donte Jackson
28 Hassan Haskins
29 Tarheeb Still
32 Alohi Gilman
36 Ja'Sir Taylor
40 Kendall Williamson
41 Rick Lovato
43 Troy Dye
44 Scott Matlock
45 Tuli Tuipulotu
48 Bud Dupree
50 Caleb Murphy
52 Khalil Mack
53 Del'Shawn Phillips
58 Marlowe Wax
68 Jamaree Salyer
73 Mekhi Becton
75 Bradley Bozeman
76 Austin Deculus
76 Joe Alt
77 Zion Johnson
78 Andre James
79 Trey Pipkins
81 Will Dissly
83 Tyler Conklin
84 Keandre Lambert-Smith
90 Teair Tart
91 Da'Shawn Hand
92 Justin Eboigbe
93 Otito Ogbonnia
99 Jamaree Caldwell

Kansas City Chiefs Substitutes

1 Xavier Worthy
2 Joshua Williams
5 Marquise Brown
6 Bryan Cook
7 Harrison Butker
8 Kristian Fulton
9 JuJu Smith-Schuster
10 Isaih Pacheco
15 Patrick Mahomes
20 Nohl Williams
21 Jaden Hicks
22 Trent McDuffie
23 Drue Tranquill
24 Brashard Smith
27 Chamarri Conner
29 Kareem Hunt
30 Christian Roland-Wallace
31 Jeffrey Bassa
32 Nick Bolton
35 Jaylen Watson
41 James Winchester
43 Jack Cochrane
49 Matt Araiza
51 Mike Danna
52 Creed Humphrey
54 Leo Chenal
56 George Karlaftis
59 Cooper McDonald
64 Wanya Morris
65 Trey Smith
66 Mike Caliendo
71 Josh Simmons
74 Jawaan Taylor
76 Kingsley Suamataia
77 Jaylon Moore
80 Tyquan Thornton
81 Nikko Remigio
83 Noah Gray
85 Robert Tonyan
87 Travis Kelce
89 Jason Brownlee
90 Charles Omenihu
91 Derrick Nnadi
92 Marlon Tuipulotu
95 Chris Jones
97 Ashton Gillotte
99 Jerry Tillery

Kansas City Chiefs Injuries

Type

Name

Info

Felix Anudike-Uzomah

Hamstring

Jake Briningstool

Hamstring

Deon Bush

Achilles

Ethan Driskell

Appendix

Brandon George

Undisclosed

Keaontay Ingram

Undisclosed

Nazeeh Johnson

Shoulder

Omarr Norman-Lott

Ankle

Rashee Rice

Suspension

Janarius Robinson

Foot

Jalen Royals

Knee

Eric Scott

Undisclosed

BJ Thompson

Chest

Los Angeles Chargers Injuries

Type

Name

Info

Junior Colson

Shoulder

Josh Fuga

Undisclosed

Josh Harris

Undisclosed

Deane Leonard

Leg

Jordan Oladokun

Undisclosed

Eric Rogers

Undisclosed

Rashawn Slater

Kneecap

Savion Washington

Undisclosed

Mike Williams

Undisclosed

Previous Kansas City Chiefs Lineups

10 Feb NFL Playoffs

Chiefs 22-40 Eagles

AFC East	PCT	Home	Road	Div	Conf	Last 5	Strk
Bills	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-
Dolphins	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-
Patriots	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-
Jets	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-

AFC North	PCT	Home	Road	Div	Conf	Last 5	Strk
Ravens	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-
Bengals	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-
Browns	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-
Steelers	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-

AFC South	PCT	Home	Road	Div	Conf	Last 5	Strk
Texans	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-
Colts	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-
Jaguars	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-
Titans	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-

AFC West	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Chargers	1	0	1.000	27	21	6	1-0-0	0-0-0	1-0-0	1-0-0	1-0-0	1W
Broncos	0	0	-	0	0	0	0-0-0	0-0-0	0-0-0	0-0-0	-	-
Raiders	0	0	-	0	0	0	0-0-0	0-0-0	0-0-0	0-0-0	-	-
Chiefs	0	1	0.000	21	27	-6	0-0-0	0-1-0	0-1-0	0-1-0	0-1-0	1L

NFC East	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Eagles	1	0	1.000	24	20	4	1-0-0	0-0-0	1-0-0	1-0-0	1-0-0	1W
Giants	0	0	-	0	0	0	0-0-0	0-0-0	0-0-0	0-0-0	-	-
Commanders	0	0	-	0	0	0	0-0-0	0-0-0	0-0-0	0-0-0	-	-
Cowboys	0	1	0.000	20	24	-4	0-0-0	0-1-0	0-1-0	0-1-0	0-1-0	1L

NFC North	PCT	Home	Road	Div	Conf	Last 5	Strk
Bears	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-
Lions	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-
Packers	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-
Vikings	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-

NFC South	PCT	Home	Road	Div	Conf	Last 5	Strk
Falcons	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-
Panthers	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-
Saints	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-
Buccaneers	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-

NFC West	PCT	Home	Road	Div	Conf	Last 5	Strk
Cardinals	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-
Rams	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-
49ers	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-
Seahawks	-	0-0-0	0-0-0	0-0-0	0-0-0	-	-

NFL Betting Preview: Chiefs vs Chargers

Head-to-Head Statistics

Chiefs vs Chargers Prediction & Picks

Game Prediction

Chargers +3 Probability

Best Bet

Player Prop Picks

Same Game Parlay Picks

Correct Score Prediction

Chiefs vs Chargers Odds

Last 5 & H2H

Team News

Kansas City Chiefs @ Los Angeles Chargers Lineups

Los Angeles Chargers

Kansas City Chiefs

Los Angeles Chargers Substitutes

Kansas City Chiefs Substitutes

Kansas City Chiefs Injuries

Los Angeles Chargers Injuries

Previous Kansas City Chiefs Lineups

Previous Los Angeles Chargers Lineups

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